منابع مشابه
Getting lamin B1 processed and organized
In This Issue In This Issue Getting lamin B1 processed and organized amins are the building blocks of the nuclear lamina, a complex polymer attached to the nuclear envelope that is thought to be important for nuclear stability, chromatin organization, and gene expression. On page 1223, Maske et al. identify the protease responsible for processing lamin B1, demonstrate the existence of a nuclear...
متن کاملGetting organized in your job.
The benefits of being organized when starting one's career are countless and worth the time and effort in developing an effective and efficient practice. Established protocols, good habits, and methodical communication that include all members of the team will help create a system that keeps all components of one's practice organized. Adhering to these strategies requires self-discipline. Apply...
متن کاملReciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective neuronal migration. The similarities in amino acid sequences, expression patterns, and knockout phenotypes raise the question of whether the two ...
متن کاملConsequences of Lamin B1 and Lamin B Receptor Downregulation in Senescence
Anchoring of heterochromatin to the nuclear envelope appears to be an important process ensuring the spatial organization of the chromatin structure and genome function in eukaryotic nuclei. Proteins of the inner nuclear membrane (INM) mediating these interactions are able to recognize lamina-associated heterochromatin domains (termed LAD) and simultaneously bind either lamin A/C or lamin B1. O...
متن کاملLamin B1 and lamin B2 are long-lived proteins with distinct functions in retinal development
Lamin B1 and lamin B2 are essential building blocks of the nuclear lamina, a filamentous meshwork lining the nucleoplasmic side of the inner nuclear membrane. Deficiencies in lamin B1 and lamin B2 impair neurodevelopment, but distinct functions for the two proteins in the development and homeostasis of the CNS have been elusive. Here we show that embryonic depletion of lamin B1 in retinal proge...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1627iti1